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I haven't read Infinite Jest and have only read snippets of David Foster Wallace's (pictured) other work [see: A Supposedly Fun Thing I'll Never Do Again & Consider the Lobster]. Overall, I don't know all that much about DFW other than that McSweeney's [see Internet Essentials - "Words"] seems intent on publishing way too many tributes to his life, that most literary minds of our generation regard him as a a writerly Superman, and that, in my eyes, his prose gleams with brilliant and shiny newness.
All opinions aside, I recommend that you settle into a comfy spot, click this link (if you didn't yet), and prepare to be walloped.